Crystallization and Preliminary X-Ray Studies of the Fab Fragment from a Humanized Version of the Mouse Anti-Human Fas Antibody Hfe7a

Authors: Ito S.; Takayama T.; Hanzawa H.; Takahashi T.; Miyadai K.; Serizawa N.; Haruyama H.; Hata T.

Source: Protein and Peptide Letters, Volume 9, Number 3, June 2002 , pp. 259-263(5)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

A humanized version of the apoptosis-inducing mouse anti-human Fas monoclonal antibody, HFE7A, is under further development for the treatment of autoimmune diseases such as rheumatoid arthritis. We have crystallized the antigen-binding fragment (Fab) of the humanized HFE7A. The crystals belong to the orthorhombic space group P2 1 2 1 2 1 with cell dimensions a = 54.4 Å, b = 82.7 Å, c = 104.9 Å and contain one Fab molecule in the asymmetric unit. X-ray diffraction data were collected to 2.8 Å resolution.

Keywords: fab fragment; humanized hfe7a; fas monoclonal antibody

Language: English

Document Type: Review article

DOI: 10.2174/0929866023408715

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy