The Effect of Fibrillar Abgr1-40 on Membrane Fluidity and Permeability

Authors: Xiaocui Ma1; Yinlin Sha1; Kechun Lin1; Songqing Nie1

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 173-178(6)

Publisher: Bentham Science Publishers

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Abstract:

The time course of Abgr fibril formation was characterized using a variety of assays. The effect of Abgr on the membrane fluidity and permeability was assessed by monitoring the anisotropy of the fluorescent probe DPH and TMA-DPH and measuring the release of vesicle-entrapped with three different molecular weight fluorescence probes (ANTS / DPX, Calcein, FD-4). The results show fibrils had formed after 4 days. Aggregated Abgrmay decrease the membrane fluidity and induce the leakage of ANTS and Calcein in a dose -dependent manner. These effects may have some relation with Abgr neurotoxicity.

Keywords: fibrillar; membrane fluidity; ants learage; calcein learage

Document Type: Review article

DOI: 10.2174/0929866023408832

Affiliations: 1: Department of Biophysics, School of Basic Medical Sciences, Peking University, Beijing 100083 P. R. CHINA

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