Skip to main content

The Effect of Fibrillar Aβ1-40 on Membrane Fluidity and Permeability

Buy Article:

$55.00 plus tax (Refund Policy)

The time course of Aβ fibril formation was characterized using a variety of assays. The effect of Aβ on the membrane fluidity and permeability was assessed by monitoring the anisotropy of the fluorescent probe DPH and TMA-DPH and measuring the release of vesicle-entrapped with three different molecular weight fluorescence probes (ANTS / DPX, Calcein, FD-4). The results show fibrils had formed after 4 days. Aggregated Aβmay decrease the membrane fluidity and induce the leakage of ANTS and Calcein in a dose -dependent manner. These effects may have some relation with Aβ neurotoxicity.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: ants learage; calcein learage; fibrillar; membrane fluidity

Document Type: Review Article

Affiliations: Department of Biophysics, School of Basic Medical Sciences, Peking University, Beijing 100083 P. R. CHINA

Publication date: 2002-04-01

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more