Flexible Crosslinked Benzhydry Support for Gel-Phase Peptide Synthesis

Authors: I.M. K. Kumar¹; Beena Mathew¹

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 167-172(6)

Publisher: Bentham Science Publishers

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Abstract:

An amphiphilic support was developed by the suspension polymerization of styrene and 1,4-butanediol dimethacrylate. The copolymer was converted to benzhydryl resin, BDDMA-PS-BH, by a two-step polymer analogous reaction. This resin was employed as a support for the synthesis of delta sleep inducing peptide (DSIP), Trp-Ala-Gly-Gly-Asp-Ala-Ser- Gly-Glu, in high yield and purity by Fmoc / t-Bu tactics.

Keywords: gel; phase peptide; delta sleep inducing peptide; solid-phase peptide

Document Type: Review article

DOI: 10.2174/0929866023408913

Affiliations: 1: School of Chemical Sciences, Mahatma Gandhi University, Kottayam - 686 560, Kerala, India.

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