Study on interaction between Duodenase - Protease with Dual Specificity and Inhibitors of Bowman-Birk Family

Authors: Inna P. Gladysheva¹; Natalia A. Popykina¹; Tatyana S. Zamolodchikova¹; Natalia I. Larionova¹

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 139-144(6)

Publisher: Bentham Science Publishers

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Abstract:

The interaction between duodenase and inhibitors of Bowman-Birk type from soybeans (BBI) and lima beans (LBI) was investigated. Duodenase was shown to interact only with antichymotrypsin site of these inhibitors. The inhibition constants of duodenase by BBI, LBI, BBI-trypsin and LBI trypsin complexes were 4, 23, 400, 600 nM respectively.

Keywords: bowman; birk family; soybeams; antichymotrypsin site; bbi; lbi trypsin complexes

Document Type: Review article

DOI: 10.2174/0929866023408878

Affiliations: 1: Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, 119899 Russia

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