Study on interaction between Duodenase - Protease with Dual Specificity and Inhibitors of Bowman-Birk Family

Authors: Inna P. Gladysheva; Natalia A. Popykina; Tatyana S. Zamolodchikova; Natalia I. Larionova

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 139-144(6)

Publisher: Bentham Science Publishers

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Abstract:

The interaction between duodenase and inhibitors of Bowman-Birk type from soybeans (BBI) and lima beans (LBI) was investigated. Duodenase was shown to interact only with antichymotrypsin site of these inhibitors. The inhibition constants of duodenase by BBI, LBI, BBI-trypsin and LBI trypsin complexes were 4, 23, 400, 600 nM respectively.

Keywords: bowman; birk family; soybeams; antichymotrypsin site; bbi; lbi trypsin complexes

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866023408878

Affiliations: 1: Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, 119899 Russia

Publication date: 2002-04-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.