Structure / Function Relationships within the Rna Recognition Motif Family applied to the Hermes Gene Product

Authors: Laurent Thion¹; Monique Erard¹

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 127-132(6)

Publisher: Bentham Science Publishers

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Abstract:

The RNA Recognition Motif (RRM) family of RNA-binding domains comprises distinct structural subclasses which can be equated to various types of cognate RNAs in relation to biological functions. By identifying structural templates within the appropriate RRM subclass, we have homology-modelled the threedimensional structure of the hermes gene-encoded RRM. Our findings lead us to propose potential RNA targets for the corresponding protein and to predict possible functions in RNA metabolism during heart development.

Keywords: rrm; rna; binding domain; cognate rna; gene; encoded rrm; rna targets

Document Type: Review article

DOI: 10.2174/0929866023408841

Affiliations: 1: Institut de Pharmacologie et de Biologie Structurale, 205 Route de Narbonne, 31077 Toulouse, France

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