Atomic Force Microscopy and Proteins

Author: Silva LP¹

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 117-125(9)

Publisher: Bentham Science Publishers

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Abstract:

This review briefly introduces the principles of atomic force microscopy (AFM) applied to protein samples. AFM provides three-dimensional surface images of the proteins with high resolution. The advantage of AFM for protein studies is that AFM can visualize directly the molecule under physiological conditions without previous treatment. AFM operated in the force-spectroscopy mode is now a widespread technique, often used to investigate ligand-receptor interactions with the goal of measuring forces at the individual molecule level.

Keywords: afm; force spectroscopy; proteins adsorption; proteins structure; probe; sample interaction; afm imaging

Document Type: Review article

DOI: 10.2174/0929866023408869

Affiliations: 1: Departamento de Genetica e Morfologia, UnB, Brasilia, DF, Brazil.

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