Recent Advances in Atomic Resolution Protein Crystallography

Authors: Luciana Esposito¹; Luigi Vitagliano¹; Lelio Mazzarella¹

Source: Protein and Peptide Letters, Volume 9, Number 2, April 2002 , pp. 95-105(11)

Publisher: Bentham Science Publishers

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Abstract:

In the search for increasingly accurate protein structures, technological advances are opening up new possibilities. In the last few years the wide accessibility of intense synchrotron sources, the availability of efficient 2D-detectors, and the routine use of cryo-crystallography techniques have yielded a significant number of atomic resolution protein structures. Here we review the most interesting results achieved in this field with a particular emphasis to the biological implications and to the correlation between protein geometry and conformation.

Keywords: synchroton sources; 2-D detectors; cryo-crystallography; atomic resolution; protein geometry; protein conformation; protein crystals; physio-chemical parameter; 3D-structures

Document Type: Review article

DOI: 10.2174/0929866023408887

Affiliations: 1: Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 6, I-80134 Napoli.

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