Renal Effects Of The Lectin From Canavalia Brasiliensis Seeds

Authors: Teixeira E.H.; Havt A.; Barbosa P.S.F.; Meneses D.B.; Fonteles M.C.; Monteiro H.S.A.; Sampaio A.H.; Cavada B.S.

Source: Protein and Peptide Letters, Volume 8, Number 6, December 2001 , pp. 477-484(8)

Publisher: Bentham Science Publishers

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Abstract:

The lectin from the seeds of Canavalia brasiliensis (Con Br) was tested for its renal effects using the isolated perfusion rat kidney method. Three different doses were examined (3,10 and 30 microgram / ml), which were compared with a control group. The control group was perfused with only Krebs-Henseleit solution containing 6 percent BSA. Con Br caused diuresis and natriuresis, with a mild alteration on the perfusion pressure. Probably the lectin is inhibiting the Na+ / K+ / 2Cl- transporter present in the thick ascending limb of the Henle?s loop.

Keywords: LECTIN; CANAVALIA; BRASILIENSIS; Diocleinae; Phaseolae; Con Br; Eicosanoids; Phaseolus vulgaris; Canavalia ensiformis

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866013409094

Publication date: 2001-12-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.