Syntheses Of Neurotensin (Nt) Analogues And Their Comparative Anorectic Effect On Food Intake In Rats

Authors: Abiko T.; Takamura Y.

Source: Protein and Peptide Letters, Volume 8, Number 6, December 2001 , pp. 461-468(8)

Publisher: Bentham Science Publishers

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Abstract:

Five analogues of neurotensin(NT:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) were prepared by the solid-phase method and their comparative anorectic effects on food intake in rats were examined. Among them, [Phe(NO2)3,11]-NT and [Phe(4F)3,11]-NT showed stronger anorectic activity than that of the parent peptide but [Tyr(Me)3,11]-NT was less active than the parent peptide. On the contrary, the other two analogues, [Sar7,10]-NT and [beta Ala7,10]-NT had no anorectic activity.

Keywords: NEUROTENSIN (NT) ANALOGUES; anorectic activity; Neurotensin (NT)

Language: English

Document Type: Review article

DOI: 10.2174/0929866013409120

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