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In Vitro Degradation Of beta-Amyloid[25-35] Peptide

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Abstract:

Some amyloid-derived peptides show their toxic effects only after a long “aging” period performed several days at pH 7.4 and 37 C for cluster formation. Our experiments show that long aging of beta-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta-amyloids.

Keywords: AMYLOID PEPTIDE; Alzheimer disease

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929866013409076

Publication date: December 1, 2001

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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