In Vitro Degradation Of beta-Amyloid[25-35] Peptide

Authors: Jost K.; Varga J.; Pence B.; Zarandi M.

Source: Protein and Peptide Letters, Volume 8, Number 6, December 2001 , pp. 423-428(6)

Publisher: Bentham Science Publishers

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Abstract:

Some amyloid-derived peptides show their toxic effects only after a long “aging” period performed several days at pH 7.4 and 37 C for cluster formation. Our experiments show that long aging of beta-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of beta-amyloids.

Keywords: AMYLOID PEPTIDE; Alzheimer disease

Language: English

Document Type: Review article

DOI: 10.2174/0929866013409076

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