Inhibition of Fungal Aldose Reductase

Authors: Ya-Jun Zheng1; Yong Tao1; Wei Zhang1; Douglas B. Jordan1

Source: Protein and Peptide Letters, Volume 8, Number 5, October 2001 , pp. 407-412(6)

Publisher: Bentham Science Publishers

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Aldose reductase (AR) was cloned from the fungal pathogen, Magnaporthe grisea, expressed in Escherichia coli and purified to homogeneity. An experimental fungicide inhibits the M. grisea AR uncompetitively with respect to its aldehyde substrate with a Ki of 130 nM, the potency suggesting that AR is a biochemical target of the fungicide. The M. grisea AR has a high kcat and large differences in substrate specificities.

Keywords: fungal ALDOSE REDUCTASE; Magnaporthe grisea

Document Type: Review article

DOI: 10.2174/0929866013409210

Affiliations: 1: DuPont Agricultural Products, Stine-Haskell Research Center, Newark, Delaware 19714, USA

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A