Inhibition of Fungal Aldose Reductase
Aldose reductase (AR) was cloned from the fungal pathogen, Magnaporthe grisea, expressed in Escherichia coli and purified to homogeneity. An experimental fungicide inhibits the M. grisea AR uncompetitively with respect to its aldehyde substrate with a Ki of 130 nM, the potency suggesting that AR is a biochemical target of the fungicide. The M. grisea AR has a high kcat and large differences in substrate specificities.
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Document Type: Review Article
Affiliations: DuPont Agricultural Products, Stine-Haskell Research Center, Newark, Delaware 19714, USA
Publication date: 2001-10-01
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