Inhibition of Fungal Aldose Reductase

Authors: Ya-Jun Zheng; Yong Tao; Wei Zhang; Douglas B. Jordan

Source: Protein and Peptide Letters, Volume 8, Number 5, October 2001 , pp. 407-412(6)

Publisher: Bentham Science Publishers

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Abstract:

Aldose reductase (AR) was cloned from the fungal pathogen, Magnaporthe grisea, expressed in Escherichia coli and purified to homogeneity. An experimental fungicide inhibits the M. grisea AR uncompetitively with respect to its aldehyde substrate with a Ki of 130 nM, the potency suggesting that AR is a biochemical target of the fungicide. The M. grisea AR has a high kcat and large differences in substrate specificities.

Keywords: fungal ALDOSE REDUCTASE; Magnaporthe grisea

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866013409210

Affiliations: 1: DuPont Agricultural Products, Stine-Haskell Research Center, Newark, Delaware 19714, USA

Publication date: 2001-10-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.