Effect of Phospholipid Membrane on Conformation of Retro-Sequence Amyloid- beeta-Peptide 35-25 and Normal Amyloid-beeta-Peptide 25-35

Author: Masato Kodaka1

Source: Protein and Peptide Letters, Volume 8, Number 5, October 2001 , pp. 395-398(4)

Publisher: Bentham Science Publishers

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Abstract:

Negatively-charged phospholipid membrane does not affect the random coil conformation of a non-neurotoxic amyloid-beeta-peptide having a retro-sequence 35-25 (Abeta 35-25), whereas it changes the conformation of a neurotoxic normal-sequence peptide A beeta 25-35 from a random coil to a beeta-sheet-like structure under the same condition. The formation of the ordered structure seems to be closely related to the expression of neurotoxicity.

Keywords: AMYLOID PEPTIDE 35-25; AMYLOID PEPTIDE 25-35; amyloid peptide

Document Type: Review article

DOI: 10.2174/0929866013409274

Affiliations: 1: Institute of Molecular and Cell Biology, Tsukuba Center, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.

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