Isolation and Structural Characterization of a Peptide from the Venom of Scorpion with Toxicity Towards Invertebrates and Vertebrates

Authors: Gerardo Corzo¹; Elba Villegas¹; Terumi Nakajima¹

Source: Protein and Peptide Letters, Volume 8, Number 5, October 2001 , pp. 385-393(9)

Publisher: Bentham Science Publishers

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Abstract:

Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.

Keywords: Leiurus quinquestriatus hebraeus; Androctonus australis; Leiurus quinquestriatus hebraeus; Androctonus australis; Leiurus quinquestriatus quinquestriatus; Hebraeus; Quinquestriatus

Document Type: Review article

DOI: 10.2174/0929866013409256

Affiliations: 1: Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618-8503, Japan.

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