Nucleolin Binds to a cis-Active Region in the Human Desmocollin 2 Promoter

Authors: Paresh L. Gadhavi1; Steven Howell1; Anthony I. Magee1; Roger S. Buxton1

Source: Protein and Peptide Letters, Volume 8, Number 5, October 2001 , pp. 349-356(8)

Publisher: Bentham Science Publishers

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Abstract:

Affinity chromatography using oligo DNA from a cis-active region (-453 / -389) of the human DSC2 promoter was used to isolate a protein from human CaCo-2 epithelial cells expressing DSC2. The protein was SDS-PAGE purified, trypsinized and analyzed by MALDI-TOF mass spectrometry. Peptide mass fingerprinting identified the protein as nucleolin, a ubiquitously expressed protein involved in gene regulation

Keywords: NUCLEOLIN; DESMOCOLLIN 2 PROMOTER; Glycoproteins; desmosomal cadherins desmocollins (DSC); desmogleins (DSG); plakoglobin (PG); plakophilin (PKP); desmoplakin (DP)

Document Type: Review article

DOI: 10.2174/0929866013409247

Affiliations: 1: Division of Membrane Biology1, Division of Protein Structure2, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom

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