Structural Studies of Herpesvirus Proteases

Authors: Renu Batra¹; Reza Khayat¹; Liang Tong¹

Source: Protein and Peptide Letters, Volume 8, Number 5, October 2001 , pp. 333-342(10)

Publisher: Bentham Science Publishers

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Abstract:

Structural studies of herpesvirus proteases establish that they belong to a new class of serine proteases and contain a novel Ser-His-His catalytic triad. Peptidomimetic inhibitors bind to the protease by forming an anti-parallel beeta-sheet with the enzyme. There are large conformational changes in the protease upon inhibitor binding, indicating that the protease is an induced-fit enzyme. Further studies are needed to understand the molecular basis for the dimerization requirement of the protease.

Keywords: HERPESVIRUS PROTEASES; Serine proteases; Peptidomimetic inhibitors; Herpes simplex virus type 1 (HSV-1); HSV-2; varicellar-zoster virus (VZV); human cytomegalovirus (HCMV); human herpes virus 6 (HHV6); HHV7; gamma herpesviruses

Document Type: Review article

DOI: 10.2174/0929866013409229

Affiliations: 1: Department of Biological Sciences, Columbia University, New York, NY 10027, USA

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