Structural Studies of Herpesvirus Proteases
Abstract:Structural studies of herpesvirus proteases establish that they belong to a new class of serine proteases and contain a novel Ser-His-His catalytic triad. Peptidomimetic inhibitors bind to the protease by forming an anti-parallel beeta-sheet with the enzyme. There are large conformational changes in the protease upon inhibitor binding, indicating that the protease is an induced-fit enzyme. Further studies are needed to understand the molecular basis for the dimerization requirement of the protease.
Keywords: HERPESVIRUS PROTEASES; HHV7; HSV-2; Herpes simplex virus type 1 (HSV-1); Peptidomimetic inhibitors; Serine proteases; gamma herpesviruses; human cytomegalovirus (HCMV); human herpes virus 6 (HHV6); varicellar-zoster virus (VZV)
Document Type: Review Article
Affiliations: Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Publication date: October 1, 2001
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