Conformation of Di-N-Propyl Glycine Residue in a Glycine Rich Peptide Sequence

Authors: Bhargava K.; Rao R.Balaji

Source: Protein and Peptide Letters, Volume 8, Number 4, August 2001 , pp. 307-315(9)

Publisher: Bentham Science Publishers

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Abstract:

The peptide Boc-(Gly-Dpg-Gly)3-OBzl (I) has been synthesized to examine the conformational preferences of Dpg residues in a peptide sequence rich in glycine, which is known to be a poor helix promoter. The detailed NMR studies revealed that peptide (I) adopts a helical conformation in CDCl3.

Keywords: Propyl Glycine; Glycine Rich Peptide

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866013409346

Publication date: 2001-08-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.