Secondary Structure of the Homologous Proteins, A A-Fetoprotein and Serum Albumin, from their Circular Dichroism and Infrared Spectra

Authors: Oberg K.A.; Uversky V.N.

Source: Protein and Peptide Letters, Volume 8, Number 4, August 2001 , pp. 297-302(6)

Publisher: Bentham Science Publishers

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Abstract:

Secondary structure composition of two homologous proteins, alpha-fetoprotein and serum albumin, has been compared using circular dichroism and Fourier-transform infrared spectroscopy. CD-only analysis gives an accurate a-helical content for SA, but underestimates the predicted value for AFP. In contrast, FTIR-only analysis underestimates the helical content of SA. However, analysis of hybrid IR-CD spectra gives more accurate values for secondary structure composition for both AFP and SA and shows that the secondary structures of these proteins are the same.

Keywords: Proteins Fetoprotein; Serum Albumin; Circular Dichroism; Human serum albumin (HSA)

Language: English

Document Type: Review article

DOI: 10.2174/0929866013409391

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