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Design of Dermaseptin S3 Analogues having Bacterial Cell Selectivity without Mammalian Cell Toxicity

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Abstract:

Dermaseptin S3 (DS3) is a a-helical antimicrobial peptide isolated from the South American frogs Phyllomedusa sauvagii. Insertion of Gly-Pro sequence into DS3 resulted in a drastic reduction in the mammalian cell toxicity against human red blood and normal fibroblast cells, with retention of the antibacterial activity. The results indicated that the bend created by insertion of Gly-Pro in the continuous a-helical peptide plays an important role in providing high selectivity against bacterial cells without mammalian cell toxicity.

Keywords: DERMASEPTIN S3 ANALOGUES; Hemolytic activity; MAMMALIAN CELL TOXICITY; Phyllomedusa sauvagii; antibacterial activity; helical antimicrobial peptide

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929866013409328

Publication date: August 1, 2001

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.

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