Skip to main content

Purification and Identification of A 25 KDa Hemorrhagin from B. atrox Venom

Buy Article:

$55.00 plus tax (Refund Policy)

Viperine and crotaline snake venoms contain one or more hemorrhagic metalloproteinases called hemorrhagins. The most potent hemorrhagins belong to P-III class and have, in adition to the protease domain, a disintegrin-like and a cysteine-rich domains. Although proteolytic degradation of vascular endothelium basement membrane has been established to be the main factor responsible for hemorrhage, several studies reveal other factors that actually do facilitate this process. In this study we report the identification of an P-I class hemorrhagin from Bothrops atrox venom. We have formerly purified an P-III class hemorrhagin from the same venom. Although exhibiting a higher proteolytic activity, the P-I class hemorrhagin showed to be a less efficient hemorrhagin when compared in vivo with the previously described P-III class metalloprotease.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Bothrops atrox; HEMORRHAGIN; P-III class; P-III class metalloprotease; hemorrhagins

Document Type: Review Article

Publication date: 2001-06-01

More about this publication?
  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more