Syntheses of Cholecystokin in (Cck) Fragment Analogues (26-33) and Comparative Effect on Decreased Feeding in Rats by Cck Fragment (26-33)

Authors: Abiko T.; Nakatsubo S.

Source: Protein and Peptide Letters, Volume 8, Number 2, April 2001 , pp. 153-158(6)

Publisher: Bentham Science Publishers

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Abstract:

The peptide analogues of cholecystokinin (CCK) fragment 26-33 in which phenylalanine residue at the 33th position are replaced by phenylglycine [Phg], 1-naphthylalanine [1-Nal], 4-fluorophenylalanine [Phe(4F)], cyclohexylalanine [cHex] and O-methyltyrosine [Tyr(Me)], were synthesized by a solid-phase method and the feeding significance of the aromatic amino acid of this position was comparatively investigated. The in vivo comparative effect on the decreased feeding in rats by peripherally CCK-8 was tested. The observed activities of these peptides were in order [Phe(4F)33]CCK-8)>.[1-Nal33]CCK-8>CCK-8>[Tyr(Me)33]CCK-8>[Phe33]CCK-8. However, the one analogue, [cHex33]CCK-8, had no inhibitory effect on food intake in rats.

Keywords: cholecystokin cck; cck; cholecystokinin cck

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866013409652

Publication date: 2001-04-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.