Triazine Conjugates for Multiple Site-Specific Labeling of Peptides

Authors: Zerkowski J.A.; Schftner D.A.

Source: Protein and Peptide Letters, Volume 8, Number 2, April 2001 , pp. 123-129(7)

Publisher: Bentham Science Publishers

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Abstract:

Mono- and di-substituted triazines were appended to the side chain of lysine or ornithine, which was then used in the synthesis of peptides. In this way, environment-sensitive reporter groups can be included in a sequence-specific manner in a peptide. The triazine adducts are stable to standard conditions employed in peptide synthesis. Several model peptides showing the utility of these conjugates were prepared

Keywords: triazine; peptides; aminochlorotriszines; fluorophores; ornithine

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929866013409562

Publication date: 2001-04-01

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Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.