Triazine Conjugates for Multiple Site-Specific Labeling of Peptides

Authors: Zerkowski J.A.; Schftner D.A.

Source: Protein and Peptide Letters, Volume 8, Number 2, April 2001 , pp. 123-129(7)

Publisher: Bentham Science Publishers

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Abstract:

Mono- and di-substituted triazines were appended to the side chain of lysine or ornithine, which was then used in the synthesis of peptides. In this way, environment-sensitive reporter groups can be included in a sequence-specific manner in a peptide. The triazine adducts are stable to standard conditions employed in peptide synthesis. Several model peptides showing the utility of these conjugates were prepared

Keywords: triazine; peptides; aminochlorotriszines; fluorophores; ornithine

Language: English

Document Type: Review article

DOI: 10.2174/0929866013409562

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