Simple And Efficient Method For Synthesis Of Z-Boc-Amino Acid Amides Using P-Toluenesulphonyl Chloride

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Abstract:

Amides of Z- and Boc protected amino acids have been prepared by using p-toluenesulphonyl chloride (TsCI) for the activation of carboxyl group. The resulting mixed carboxylic-sulphonic anhydride intermediate was treated in situ with an excess of 25 percent ammonia solution. All the amino acid amides prepared were obtained as crystalline solids in good yield and purity.
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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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