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Isolation And Characterization Of Two Distinct Atp-Independent Topoisomerase Ii Activities From The Trypanosomatid Trypanosoma Brucei Brucei

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In a rapid purification procedure, two distinct type II topoisomerase activities (decatenation and catenation) have been isolated from the whole cell extracts of Trypanosoma brucei brucei. Both decatenating and catenating activities were detected in the cell extracts, but these two activities were separated in the last step of purification. These two activities were found to be independent of each other and competent both in the presence and absence of 1 mm ATP.

Keywords: (decatenation and catenation); ATP; Leishmania donovani; TOPOISOMERASE II; TRYPANOSOMA BRUCEI BRUCEI; kDNA; knotting/unknotting reactions

Document Type: Review Article


Publication date: 2001-02-01

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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