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Exploring Protein-Protein Interactions with Synthetic Peptide Arrays

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Development of array technologies started in the late 1980s, and today this technique has become a powerful tool for high throughput approaches in biology and chemistry. Progress was mainly driven by the human genome project and associated with the development of several new technologies, leading to the birth of additional “omic” topics such as proteomics, glycomics, or antibodyomics. In this review we focus strictly on peptide arrays applied to investigate protein-protein interactions, starting from single events up to complete interaction networks (interactomes). The specificities and interaction networks of protein interaction domains (PIDs) are our central theme. Picking practical examples from the literature, we review some general concepts about peptide arrays on planar supports for mapping protein-protein interactions.

Keywords: PIDs; Peptide arrays; SPOT technology; human genome project; omic; peptide microarrays; protein interaction domains; protein-protein interactions

Document Type: Research Article


Publication date: 2011-05-01

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  • Mini-Reviews in Organic Chemistry publishes original reviews on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly. Mini-reviews will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts.

    The journal is essential reading to all organic chemists in both academia and industry.
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