The Concept of a Green Drug, Curcumin and It's Derivatives as a Model System

Authors: Raja, K. S.; Balambika, R.; Dolai, S.; Shi, W.

Source: Mini-Reviews in Organic Chemistry, Volume 6, Number 2, May 2009 , pp. 152-158(7)

Publisher: Bentham Science Publishers

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Abstract:

Only 5-15% of the ∼25000 existing species of plants have been examined for the presence of biologically active compounds. The ancient medical systems use a much larger palette of herbs for therapy. Systematic drug discovery involving using cues provided from traditional medical systems is bound to produce a new generation of green drugs. Curcumin the primary active ingredient in Curcuma longa is used as a model to enunciate the concept of green drug development. Synthetic and formulation based approaches to optimize the bioactivity of curcumin is presented.

Keywords: Green drug; curcumin; traditional medicine; GRAS; renewable resource; derivative

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157019309788167684

Publication date: 2009-05-01

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