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Pseudopeptide Synthesis via Fmoc Solid-Phase Synthetic Methodology

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Peptidomimetic modifications are frequently used as attractive methods to provide more conformationally constrained and thus more stable and bioactive peptides. Among peptidomimetic approaches, particularly attractive are pseudopeptides, or peptide bond surrogates in which peptide bonds have been replaced with other chemical groups. Since these peptidomimetics can be constructed in a modular way from orthogonally protected monomeric building blocks, solid-phase Fmoc methodology, used routinely for peptide synthesis, emerged as a particularly attractive synthetic approach.

Keywords: Fmoc solid-phase synthesis; Peptidomimetics; isosteres; pseudopeptides

Document Type: Research Article

Publication date: 2007-11-01

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