The Furan-2(5H)-ones: Recent Synthetic Methodologies and its Application in Total Synthesis of Natural Products

Author: De Souza, Marcus Vinicius N.1

Source: Mini-Reviews in Organic Chemistry, Volume 2, Number 2, April 2005 , pp. 139-145(7)

Publisher: Bentham Science Publishers

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Abstract:

In recent years, furan-2(5H)-ones have attracted considerable attention as synthetic target. This subunit is present in a large number of natural products, which display a wide range of biological activities, and is present in a number of drugs with diverse biological activities, such as antifungal, antibacterial and anti-inflammatory. It can also be used as synthetic intermediate. This review describes recent synthetic methodologies for preparation of furan-2(5H)-ones, as well as their application in the total synthesis of natural products with this subunit.

Keywords: furan-2(5h)-ones; biologic activity; natural products; synthetic methodologies

Document Type: Review article

DOI: 10.2174/1570193053544427

Affiliations: 1: Fundacao Oswaldo Cruz,Instituto de Tecnologia em Farmacos-Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro - RJ, Brazil.

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