The Furan-2(5H)-ones: Recent Synthetic Methodologies and its Application in Total Synthesis of Natural Products

Author: De Souza, Marcus Vinicius N.

Source: Mini-Reviews in Organic Chemistry, Volume 2, Number 2, April 2005 , pp. 139-145(7)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

In recent years, furan-2(5H)-ones have attracted considerable attention as synthetic target. This subunit is present in a large number of natural products, which display a wide range of biological activities, and is present in a number of drugs with diverse biological activities, such as antifungal, antibacterial and anti-inflammatory. It can also be used as synthetic intermediate. This review describes recent synthetic methodologies for preparation of furan-2(5H)-ones, as well as their application in the total synthesis of natural products with this subunit.

Keywords: furan-2(5h)-ones; biologic activity; natural products; synthetic methodologies

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570193053544427

Affiliations: 1: Fundacao Oswaldo Cruz,Instituto de Tecnologia em Farmacos-Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro - RJ, Brazil.

Publication date: 2005-04-01

More about this publication?

Mini-Reviews in Organic Chemistry publishes original reviews on all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly. Mini-reviews will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts.

The journal is essential reading to all organic chemists in both academia and industry.