The Chemistry and Biology of Rhazinilam and Analogues

Authors: Baudoin O.; Guenard D.; Gueritte F.

Source: Mini-Reviews in Organic Chemistry, Volume 1, Number 3, July 2004 , pp. 333-341(9)

Publisher: Bentham Science Publishers

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Abstract:

Rhazinilam (1) is a natural substance with unique tubulin-binding properties. The present review describes the isolation and structure elucidation of (1), the available data regarding its biological properties, its semi- and total syntheses and its structure-activity relationships through the synthesis of analogues.

Keywords: rhazinilam; tubulin; structure-activity relationships; semisynthesis; total synthesis; analogues

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570193043403226

Affiliations: 1: Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur- Yvette Cedex, France

Publication date: 2004-07-01

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