DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs

Authors: Kuzuya A.; Zhou J..M.; Komiyama M.

Source: Mini-Reviews in Organic Chemistry, Volume 1, Number 1, January 2004 , pp. 125-131(7)

Publisher: Bentham Science Publishers

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Abstract:

Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.

Keywords: snp genotyping; rna; pna; selective scission; acridine; nuclease

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570193043488999

Affiliations: 1: Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904 Japan.

Publication date: 2004-01-01

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