Combinatorial Carbohydrate Synthesis

Authors: Baytas S.N.¹; Linhardt R.J.¹

Source: Mini-Reviews in Organic Chemistry, Volume 1, Number 1, January 2004 , pp. 27-39(13)

Publisher: Bentham Science Publishers

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Abstract:

Combinatorial chemistry has contributed to the preparation of biologically important oligosaccharide and glycoconjugate libraries, with a view of improving our understanding of the complex interaction between the carbohydrates and their proteinbased receptors. The combinatorial carbohydrate synthesis strategies, developed in the past decade, provide access to small and medium size libraries. This mini review critically examines both the solution phase and solid phase strategies that have been reported to date.

Keywords: combinatorial chemistry; carbohydrates; solution phase synthesis; solid phase synthesis; glycoconjugates

Document Type: Review article

DOI: 10.2174/1570193043488917

Affiliations: 1: Department of Chemistry, RPI, 110 8th Street, Troy, NY, 12180-3590, USA.

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