Authors: Yan, Fei; Mu, Ying; Yan, Ganglin; Liu, Junqiu; Shen, Jiacong; Luo, Guimin

Source: Mini Reviews in Medicinal Chemistry, Volume 10, Number 4, April 2010 , pp. 342-356(15)

Publisher: Bentham Science Publishers

Abstract:

The antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase contribute dominatingly to enhance cellular antioxidant defense against oxidative stress. They act cooperatively to scavenge reactive oxygen species, and not one of them can singlehandedly clear all forms of reactive oxygen species. On the basis of the structural understanding for these natural enzymes, many mimics with multifunctional activities had been obtained by chemical synthesis, biosynthesis, and protein fusion techniques. Some of them display remarkable antioxidant cooperative effect in living model which possess potential application in medicine as potent antioxidants. This review summarizes aspects of some multifunctional mimics which have been reported so far.

Keywords: Superoxide dismutase (SOD); catalase (CAT); glutathione peroxidase (GPx); glutathione S-transferases (GST); reactive oxygen species (ROS); antioxidant enzymes; enzyme mimics; synergism

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955710791330972

Publication date: 2010-04-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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