Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents
Authors: Xiao, Guizhi; Fang, Hao; Xing, Chengguo; Xu, Wenfang
Source: Mini Reviews in Medicinal Chemistry, Volume 9, Number 14, December 2009 , pp. 1596-1604(9)
Publisher: Bentham Science Publishers
Abstract:Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
Document Type: Research Article
Publication date: 2009-12-01
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