Authors: Cazarolli, Luisa H.; Zanatta, Leila; Alberton, Elga H.e.l.o.i.s.a.; Reis Bonorino Figueiredo, Maria S.a.n.t.o.s.; Folador, Poliane; Damazio, Rosangela G.u.o.l.l.o.; Pizzolatti, Moacir G.e.r.a.l.d.o.; Mena Barreto Silva, Fatima R.e.g.i.n.a.

Source: Mini Reviews in Medicinal Chemistry, Volume 8, Number 10, September 2008 , pp. 1032-1038(7)

Publisher: Bentham Science Publishers

Abstract:

The purpose of this review is to discuss the cellular and molecular mechanisms of action of flavonoids focusing on carbohydrate metabolism. The beneficial effects of flavonoids have been studied in relation to diabetes mellitus, either through their capacity to avoid glucose absorption or to improve glucose tolerance. Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.

Keywords: Flavonoids; mechanism of action; glycemia; insulin; diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955708785740580

Publication date: 2008-09-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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• In this Subject: Chemistry (General) ,  Pharmacology
• By this author: Cazarolli, Luisa H. ;  Zanatta, Leila ;  Alberton, Elga H.e.l.o.i.s.a. ;  Reis Bonorino Figueiredo, Maria S.a.n.t.o.s. ;  Folador, Poliane ;  Damazio, Rosangela G.u.o.l.l.o. ;  Pizzolatti, Moacir G.e.r.a.l.d.o. ;  Mena Barreto Silva, Fatima R.e.g.i.n.a.

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