Which Treatment for Nonalcoholic Fatty Liver Disease?

Authors: Moscatiello, S.; Marzocchi, R.; Villanova, N.; Bugianesi, E.; Marchesini, G.

Source: Mini Reviews in Medicinal Chemistry, Volume 8, Number 8, July 2008 , pp. 767-775(9)

Publisher: Bentham Science Publishers

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Abstract:

Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.

Keywords: Orlistat; weight loss; Metformin; statins; Lipid peroxidation; diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955708784912193

Publication date: 2008-07-01

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