Author: Szolnoki, Zoltan

Source: Mini Reviews in Medicinal Chemistry, Volume 7, Number 5, May 2007 , pp. 529-532(4)

Publisher: Bentham Science Publishers

Abstract:

An increasing body of evidence suggests that different genetic factors, such as angiotensin-converting enzyme (ACE) I/D , angiotensin II type-1 receptor (AT1R) A1166C, methylenetetrahydrofolate reductase (MTHFR) C677T and ENOS G894T variants are associated with an endothelial dysfunction (ED). EDs are relatively new phenomena that are presumed to contribute to vasoregulatory malfunctions at the small-vessel level. Ever more clinical observations indicate that the above genetic variants are also associated with cerebral small-vessel disorders. This article reviews the knowledge available on the roles of ED- associated genetic variants in cerebral circulatory disorders, and suggests that EDs can be causative factors for different common cerebral pathologies such as leukoaraiosis or/and small-vessel infarcts. Newly-developed drugs involving phosphodiesterase type-5 inhibitors, which improve the endothelial functions, may comprise a new approach to the treatment and prevention of small-vessel cerebral circulatory disorders.

Keywords: Leukoaraiosis; small-vessel infarcts; endothelial dysfunction; nitric oxide; endothelin-1; MTHFR C677T; angiotensin-converting enzyme I/D; ENOS G894T; AT1R A1166C; genetic variant

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955707780619572

Affiliations: 1: Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, H-5600 Bekescsaba,Pipacs koz 9, Hungary.

Publication date: 2007-05-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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