Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing

Authors: Bitto, A.; Minutoli, L.; Squadrito, F.; Polito, F.; Altavilla, D.

Source: Mini Reviews in Medicinal Chemistry, Volume 7, Number 3, March 2007 , pp. 339-343(5)

Publisher: Bentham Science Publishers

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Abstract:

Raxofelast, also named IRFI 016 or (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid, belongs to a family of novel molecules designed with the aim to maximize antioxidant potency of phenols related to Vitamin E ( α-tocopherol). This review will focus on the antioxidant and radical scavenging activity of this new promising compound.

Keywords: Raxofelast; inflammation; ischemia/reperfusion injury; wound healing; diabetes; safety

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955707780059835

Affiliations: 1: the Section of Pharmacology,Department of Experimental, And Clinical Medicine and Pharmacology,Torre Biologica 5th floor, “AOU” Policlinico G. Martino, Via C. Valeria Gazzi, 98124 Messina, Italy.

Publication date: 2007-03-01

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