Authors: Chattopadhyay, Debprasad; Naik, Trailokya N.

Source: Mini Reviews in Medicinal Chemistry, Volume 7, Number 3, March 2007 , pp. 275-301(27)

Publisher: Bentham Science Publishers

Abstract:

Ethnomedicinal plants have been used as source of candidate drugs for almost all diseases, but the number of compounds having antiviral activity is scarce. Irrespective of type of viruses and the cells they infect, there are a very few specific viral targets for the natural molecules to interact. Most of the available antiviral drugs often lead to the development of viral resistance coupled with the problem of side effects, recurrence and viral latency. A wide array of ethnomedicinal plants showed high level of antiviral activities and many of them have complementary and overlapping mechanism of action, either inhibiting viral replication, or viral genome synthesis. Hence, there is an urgent need to develop new antivirals of natural origin. This review will cover some of the promising antiviral compounds isolated from ethnomedicinal plants with proven in vitro and some documented in vivo activities, along with their structure activity relationship.

Keywords: Ethnomedicine; antivirals; structure activity relationship (SAR); HSV; HIV

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955707780059844

Affiliations: 1: Division of Virology, National Institute of Cholera and Enteric Diseases, P-33, CIT Road Scheme XM, Beliaghata, Kolkata 700010, India.

Publication date: 2007-03-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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