Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants

Authors: Liu, Quan¹; Xie, Fang¹; Rolston, Raj¹; Moreira, Paula I.¹; Nunomura, Akihiko¹; Zhu, Xiongwei¹; Smith, Mark A.¹; Perry, George¹

Source: Mini Reviews in Medicinal Chemistry, Volume 7, Number 2, February 2007 , pp. 171-180(10)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

There is considerable evidence showing that oxidative damage is one of the earliest neuronal and pathological changes of Alzheimer disease and many, if not all, of the etiological and pathological causes of the disease are related, directly or indirectly, to free radical production and oxidative damage. Here we summarize the current body of knowledge suggestive that oxidative damage is, if not the key factor, certainly a major factor in Alzheimer disease. As such, therapeutic modalities encompassing antioxidants may be an effective approach to the treatment of neurodegenerative diseases and delay the aging process.

Keywords: Antioxidant; calorie restriction; estrogen; free radical; glutathione; oxidation; oxidative stress; sirtuin; therapy; vitamin C

Document Type: Research article

DOI: 10.2174/138955707779802552

Affiliations: 1: Department of Ophthalmology,University of California, San Diego, 9500 Gilman Drive # 0946, La Jolla, California 92093-0946 USA.

Your trusted access to this article has expired.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy