Natural and Synthetic Cholera Toxin Antagonists

Authors: Velter, I. A.1; Politi, M.1; Podlipnik, C.1; Nicotra, F.1

Source: Mini Reviews in Medicinal Chemistry, Volume 7, Number 2, February 2007 , pp. 159-170(12)

Publisher: Bentham Science Publishers

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Abstract:

Cholera Toxin (CT) recognizes the cell membrane through specific interactions with ganglioside GM1. Recent structural elucidation of the CT/GM1 complex has allowed the rational design of artificial receptors for the toxin, which could function as anti-cholera drugs. The efforts towards the rational design of Cholera Toxin inhibitors will be presented.

Keywords: Cholera toxin; ganglioside GM1; catechins; galactose; multivalency

Document Type: Research article

DOI: 10.2174/138955707779802589

Affiliations: 1: Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milano, Italy.

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