Anti-Bacterial Drug Discovery Using Systems Biology

Author: Kumble, K. D.

Source: Mini Reviews in Medicinal Chemistry, Volume 6, Number 11, November 2006 , pp. 1275-1283(9)

Publisher: Bentham Science Publishers

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Abstract:

The pipeline for new antibacterials is bleak despite the fact that infectious diseases account for a quarter of all worldwide deaths due to disease. Bacteria are ideal organisms for a systems biology approach to understanding pathogenesis by combined use of genomic technologies and computer algorithms. This approach can be applied to identify control points in molecular networks, which could be targets for novel drugs.

Keywords: Genomics; systems biology; molecular networks; antibacterials; pathogens

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955706778742803

Affiliations: 1: Genesis Research and Development Corporation Limited, One Fox Street, Parnell, Auckland, New Zealand.

Publication date: 2006-11-01

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