Authors: Carta, A.; Piras, S.; Loriga, G.; Paglietti, G.

Source: Mini Reviews in Medicinal Chemistry, Volume 6, Number 11, November 2006 , pp. 1179-1200(22)

Publisher: Bentham Science Publishers

Abstract:

Quinoxaline derivatives have received much attention in recent years owing to their both biological properties and pharmaceutical applications. In this review we focus the attention on quinoxalin-2(3)-ones and quinoxalin-2,3-diones. These derivatives are particularly interesting since some of them showed antimicrobial (against several bacteria, viruses, fungi, etc), or anticancer activities. Furthermore, others are reported to be potent no-NMDA glutamate receptor antagonists, endowed with anxiolytic, deconditioning, analgesic, antispastic, antiallergic, antithrombotic activities. In this article we also report SAR studies and the most important methods of synthesis of the quinoxalin-2(3)-(di)ones.

Keywords: Quinoxalin-2(3)-ones; quinoxalin-2,3-diones; AMPA antagonists; GlyN antagonists; antimicrobial activity; anticancer activity; Pgp antagonists; antiallergic activity; antithrombotic activity; SAR studies

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138955706778742713

Affiliations: 1: Dipartimento Farmaco Chimico Tossicologico, Facolta di Farmacia, Universita di Sassari, via Muroni 23/a, 07100 Sassari, Italy.

Publication date: 2006-11-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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