Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses

Authors: Martin, Stefan F.¹; Merfort, Irmgard¹; Thierse, Hermann-Josef¹

Source: Mini Reviews in Medicinal Chemistry, Volume 6, Number 3, March 2006 , pp. 247-255(9)

Publisher: Bentham Science Publishers

Abstract:

Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.

Keywords: Allergic contact dermatitis; skin sensitization; chemical; metalion; hapten; arnica; nickel; proteomics

Document Type: Research article

DOI: 10.2174/138955706776073493

Affiliations: 1: Department of Dermatology, Clinical Research Group Allergology, University of Freiburg, Hauptstrasse 7, D-79104 Freiburg, Germany.

Links for this article

http://www.ingentaconnect.com/ben/mrmc/2006/00000006/00000003/art00001
http://openurl.ingenta.com/content?genre=article&issn=1389-5575&volume=6&issue=3&spage=247&epage=255
http://dx.doi.org/10.2174/138955706776073493