Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?

Authors: Jahn, Olaf; Radulovic, Jelena; Stiedl, Oliver; Tezval, Hossein; Eckart, Klaus; Spiess, Joachim

Source: Mini Reviews in Medicinal Chemistry, Volume 5, Number 10, October 2005 , pp. 953-960(8)

Publisher: Bentham Science Publishers

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Abstract:

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

Keywords: corticotropin-releasing factor (crf); crf binding protein (crfbp); crfbp inhibitor; urocortin; cognitive deficits

Document Type: Review article

DOI: http://dx.doi.org/10.2174/138955705774329500

Affiliations: 1: Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Goettingen, Germany.

Publication date: 2005-10-01

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The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.