Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?

Authors: Jahn, Olaf1; Radulovic, Jelena1; Stiedl, Oliver1; Tezval, Hossein1; Eckart, Klaus1; Spiess, Joachim1

Source: Mini Reviews in Medicinal Chemistry, Volume 5, Number 10, October 2005 , pp. 953-960(8)

Publisher: Bentham Science Publishers

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Abstract:

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

Keywords: corticotropin-releasing factor (crf); crf binding protein (crfbp); crfbp inhibitor; urocortin; cognitive deficits

Document Type: Review article

DOI: 10.2174/138955705774329500

Affiliations: 1: Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Goettingen, Germany.

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