Recent Methodologies for the Estimation of N-Octanol / Water Partition Coefficients and their Use in the Prediction of Membrane Transport Properties of Drugs

Authors: Gilles Klopman; Hao Zhu

Source: Mini Reviews in Medicinal Chemistry, Volume 5, Number 2, February 2005 , pp. 127-133(7)

Publisher: Bentham Science Publishers

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Abstract:

The lipophilicity of drug molecules (represented as the logarithm of the n-octanol / water partition coefficient) often strongly correlates with their pharmacological and toxic activities. It is therefore, not surprising that there is considerable interest in developing mathematical models capable to accurately predict their value for new drug candidates.

In this review, current major approaches for estimating partition coefficients are described and some of their advantages and disadvantages are discussed. Recent uses of these partition coefficient algorithms in the development of membrane transport models are also discussed.

Keywords: lipophilicity; partition coefficient; membrane transport; qsar

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557053402765

Affiliations: 1: Department of Chemistry,Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA.

Publication date: 2005-02-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.