Authors: Hugo Cerecetto; Williams Porcal

Source: Mini Reviews in Medicinal Chemistry, Volume 5, Number 1, January 2005 , pp. 57-71(15)

Publisher: Bentham Science Publishers

Abstract:

The chemistry of furoxans (1, 2, 5-oxadiazole-2-oxides) and benzofuroxans (benzo[1, 2-c]1, 2, 5- oxadiazole-1-oxides) is very well known. These systems are widely used in organic chemistry as intermediate compounds for the synthesis of numerous heterocycles.

In the other hand, furoxan and benzofuroxan derivatives were extensively studied as bioactive compounds. They possess remarkable biological activities, such as anti-microbial and anti-parasitic properties, mutagenic, immunosuppressive and anticancer effects, anti-aggregating and vasorelaxant activity, among others. In some cases, molecular mode of action was proposed.

Recently, the research and development in the medicinal chemistry of these systems have produced hybrid compounds in which furoxan or benzofuroxan moieties together with a classical drug moieties are present in a single molecule. So, new anti-ulcer drugs, calcium channel modulators and vasodilator derivatives were described and they are currently in study.

In this presentation recent developments in the medicinal chemistry of furoxans and benzofuroxans will be reviewed.

Keywords: benzofuroxans; isomerization; nmr spectroscopy; intramolecular cyclization; antibacterial

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557053402864

Affiliations: 1: Departamento de Quimica Organica. Facultad de Quimica y Facultad de Ciencias, Universidad de la Republica. Igua 4225, 11400 Montevideo, Uruguay.

Publication date: 2005-01-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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