Development of Radioligands for In Vivo Imaging of GABAA-Benzodiazepine Receptors

Authors: Andrew Katsifis; Michael Kassiou

Source: Mini Reviews in Medicinal Chemistry, Volume 4, Number 8, October 2004 , pp. 909-921(13)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

Changes in the biochemical integrity and function of the GABAA-benzodiazepine receptor (BZR) complex have been implicated in various neurological and psychiatric disorders. The development of specific radioligands for the GABAA-BZR have not only contributed to the elucidation of the receptor's biochemical functions, but also provided a means by which these changes are correlated to disease states when studied with the functional imaging modalities of positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Keywords: benzodiazepines; cns receptors; radioligands; pet; spect

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557043403332

Affiliations: 1: Radiopharmaceuticals Division R & D, Australian Nuclear Science and Technology Organisation Private Mail Bag 1, Menai NSW 2234, Sydney, Australia.

Publication date: 2004-10-01

More about this publication?

The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.