Authors: Chakraborty C.; Mungantiwar A.A.

Source: Mini Reviews in Medicinal Chemistry, Volume 3, Number 5, August 2003 , pp. 375-385(11)

Publisher: Bentham Science Publishers

Abstract:

Insulin is a essential molecule for type I diabetes that is marketed by very few companies. It is the first molecule, which was made by recombinant technology; but the commercialization process is very difficult. Knowledge about biochemical structure of insulin and human insulin genome sequence map is pivotal to large scale manufacturing of recombinant DNA Insulin. This paper reviews human insulin genome sequence map, the amino acid sequence of porcine insulin, crystal structure of porcine insulin, insulin monomer, aggregation surfaces of insulin, conformational variation in the insulin monomer, insulin X-ray structures for recombinant DNA technology in the synthesis of human insulin in Escherichia coli.

Keywords: Human Insulin; DNA technology; Genome Sequence Map

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557033488024

Affiliations: 1: Departmet of Biotechnology and Medical Science, Macleods Pharmaceuticals Ltd ,3rd floor,Atlanta Arcade, Moral Church Road, Andheri(East), Mumbai-400059 India.

Publication date: 2003-08-01

More about this publication?

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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