Nerve Membrane Ion Channels as the Target Site of Insecticides

Author: Narahashi T.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 4, August 2002 , pp. 419-432(14)

Publisher: Bentham Science Publishers

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Abstract:

Most insecticides are potent neurotoxicants that act on various neuroreceptors and ion channels. However, the major target receptors are limited to sodium channels, GABA receptors, and nicotinic acetylcholine receptors. DDT and pyrethroids act similarly on sodium channels to keep them open leading to hyperexcitation. Indoxacarb inhibits sodium channels and certain subtypes of nicotinic receptors. Dieldrin, lindane and fipronil block GABA receptors. Imidacloprid modulates nicotinic receptors in a complex manner. Spinosad's major target site appears to be nicotinic receptors.

Keywords: imidacloprid; insecticide; Ion channel; neurotoxicant; indoxacarb

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557023405927

Publication date: 2002-08-01

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The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.