Selective Agonists and Antagonists for Kainate Receptors

Authors: Conti P.; Amici M.De; Micheli C.De

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 2, April 2002 , pp. 177-184(8)

Publisher: Bentham Science Publishers

Abstract:

Kainate receptors have only recently been characterized both from the pharmacological and biological point of view. Due to the limited number of truly kainate selective ligands, most of the known agonists and antagonists are generally classified as AMPA / kainate receptors ligands. The increasing interest in the search for selective kainate ligands aims at understanding the physiological role played by these receptors and finding out potential therapeutic approaches for the treatment of a number of neurological pathologies, i.e. schizophrenia, as well as acute and chronic neurodegenerative diseases, i.e. epilepsy, cerebral ischaemia, Parkinson's and Alzheimer's diseases. This review will focus on the recently discovered ligands for kainate receptors, with a particular attention given to those molecules displaying a selectivity for the different subunits of the kainate receptors and, on the other hand, to the role played by these receptor subtypes in the pathophysiology of the central nervous system.

Keywords: kainte receptors; kainic acid; domoic acid

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557024605456

Publication date: 2002-04-01

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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• In this Subject: Chemistry (General) ,  Pharmacology
• By this author: Conti P. ;  Amici M.De ;  Micheli C.De

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