QRAR Models for Central Nervous System Drugs using Biopartitioning Micellar Chromatography

Authors: Quinones-Torrelo C.; Martin-Biosca Y.; Martinez-pla J.J.; Sagrado S.; Villanueva-Camanas R.M.; Medina-Hernandez M.J.

Source: Mini Reviews in Medicinal Chemistry, Volume 2, Number 2, April 2002 , pp. 145-161(17)

Publisher: Bentham Science Publishers

Abstract:

The capability of biopartitioning Micellar Chromatography, BMC, to describe and estimate pharmacokinetic and pharmacodynamic parameters of central nervous system drugs is reviewed in this article. BMC is a mode of micellar liquid chromatography, MLC, that uses micellar mobile phases of Brij35 (polyoxyethilene(23) lauryl ether) prepared in physiological conditions (pH, ionic strength). The retention of a drug in this system depends on its hydrophobic, electronic and steric properties, which also determine its biological activity. The results of BMC studies suggest that this in vitro approach is an attractive useful tool to be implemented into the lead optimization step of drug development scheme.

Keywords: biopartitioning micellar chromatography(bmc); hypnotics; sedatives; antipsychotic drugs; anticonvulsants; tricyclic antidepressant; drug toxicity

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389557024605519

Publication date: 2002-04-01

• The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
  
  The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
  
  Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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• In this Subject: Chemistry (General) ,  Pharmacology
• By this author: Quinones-Torrelo C. ;  Martin-Biosca Y. ;  Martinez-pla J.J. ;  Sagrado S. ;  Villanueva-Camanas R.M. ;  Medina-Hernandez M.J.

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